News reports indicate that demand for both initial Covid vaccination as well as booster shots continue to fall precipitously. Yet compelled vaccination continue to be mandated by many employers, including the United States military, which has discharged thousands of service members unwilling to get the vaccine. Still other employers, notably medical facilities, have imposed booster mandates on their employees. Many colleges and universities imposed similar mandates on their students at the beginning of the Spring semester.
Notably, all of these shots continue to use the original, long-extinct wild-type variant contained in the first generation of vaccines. This repeated administration of vaccines raises a risk of effects known as original antigenic sin (OAS) and antigenic seniority that, aside from a few exceptions, public health officials have not addressed.
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