Orforglipron is an oral drug from Eli Lilly that’s in trial stage. The New York Times reports that in a trial of over 500 patients, those “who took the highest dose lost an average of around 16 pounds after nine months.” The Times added that roughly “two-thirds of people who took the drug also saw their blood sugar levels fall to target range.”
Which is at first glance a comment that markets work. Diets and exercise have long failed exactly because they’re non sequiturs relative to the true cause of weight gain: appetite. That’s why weight for so many has fluctuated for so long. Diets don’t fix what causes weight gain in the first place, while exercise runs against millennia worth of evolution during which humans walked and ran all day and night in search of calories in brutally limited supply.
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